Zepbound® vs. Mounjaro®: Which is best for weight loss?

What you’ll learn:       

• Zepbound^® and Mounjaro^® contain the same active ingredient and are produced by the same company. 
• They are approved for different uses: Zepbound^® is FDA-approved for weight management, while Mounjaro^® is approved for type 2 diabetes treatment but can be prescribed off-label for weight loss.
• The choice between Zepbound^® and Mounjaro^® often depends on what you are treating, insurance coverage, and health needs.

When it comes to medications that assist with weight management, the options can seem overwhelming. Understanding how each works—and the intended uses—can help you make informed decisions about what’s right for your health. Tirzepatide, the active ingredient in both Zepbound^® and Mounjaro^®, is gaining attention for its dual ability to manage type 2 diabetes and promote significant weight loss. But what exactly sets these two medications apart, and how do they work?

Zepbound^® and Mounjaro^® are two different brand names for tirzepatide. Tirzepatide is considered a GLP-1 medication because it mimics the hormone GLP-1 to help people lose weight and manage diabetes. But unlike other medications, it also mimics a hormone called GIP hormone, which helps to increase the appetite suppression effects. This means it might be more effective for weight loss for some people. 

While these medications contain the same active ingredient, they are approved for different uses. Zepbound^® is specifically approved for weight management, while Mounjaro^® is primarily prescribed for the management of type 2 diabetes. It can also be prescribed off-label for weight loss. 

How do you decide which one might be the better fit? If you qualify for Noom Med, you will be paired with a clinician who can discuss all of your medical weight loss options and prescribe the right one for you, if necessary. Let’s discuss what makes these medications unique and how they could support your health goals!

Zepbound^® vs. Mounjaro^®: Do they work the same way?

Zepbound^® and Mounjaro^® are the exact same medication (tirzepatide) under different names produced by the same company, Eli Lilly. Both medications are dosed similarly, with a maximum of 15 milligrams per week. They are also administered the same way: as a once-weekly injection in the upper arm, thigh, or belly. 

Tirzepatide targets two hormones in the body—GLP-1 (glucagon-like peptide 1) and GIP (glucose-dependent insulinotropic polypeptide). These hormones are secreted by the intestines when you eat, and they stimulate the pancreas to release insulin. Here’s what you can expect to experience with both Zepbound^® and Mounjaro^®:

• Greater appetite control: By activating GLP-1 and GIP receptors, both medications reduce appetite.
• Slower digestion: They also delay stomach emptying, which makes you feel fuller longer. 
• A metabolism boost: These medications can also boost your metabolism.

Zepbound^® vs. Mounjaro^®: How are they different?

The main difference between Zepbound^® and Mounjaro^®, besides their names, lies in their FDA-approved uses. 

• Mounjaro^® was approved by the FDA in May 2022 to treat type 2 diabetes. However, it’s also prescribed off-label for weight loss because of its effectiveness in helping patients shed pounds. 
• Zepbound^® got FDA approval in November 2023 for weight management. It’s intended for adults with a BMI of 30 or higher or 27 or higher who have a weight-related condition like high blood pressure or high cholesterol.

Zepbound^® vs. Mounjaro^®: Do they cost the same?

Zepbound^® and Mounjaro^® have similar costs, but what you will end up paying depends on various factors. The list price for a 28-day supply of Zepbound^® is about $1,060, while Mounjaro^® is listed at about $1,070. Insurance coverage for these medications varies depending on individual plans, and not all policies may cover them. To help offset costs, manufacturer savings cards are available, offering eligible people financial assistance. 

Zepbound^®’s manufacturer, Eli Lilly, created another option in September 2024 to make the medication more affordable for some people. People with a prescription from their doctor can order new single-use vials directly through Eli Lilly’s LillyDirect platform. These vials are significantly more affordable: $399 for the 2.5 mg dose and $549 for the 5.0 mg dose, both available in four-dose packages, so about a month’s worth. They cost less because they are in vial and syringe format instead of pre-loaded injector pens.

Still too expensive? You have options. If you qualify for Noom Med, we’ll pair you with a clinician who can assess whether compounded semaglutide* through Noom GLP-1^Rx is right for you. This medication contains the same active ingredient as Ozempic^® and Wegovy^® but starts at just $149 for the first month. If prescribed, it will be on its way to you in seven days. It comes with full Noom Med support and Noom’s healthy eating advice, trackers, and exercise library. 

Zepbound^® vs. Mounjaro^®: Will I be able to find them in stock? 

Maybe. For a while, as these medications grew in popularity, pharmacies struggled to keep them in stock, leading to widespread delays for many patients. Essentially, Eli Lilly could not produce enough of either medication because of its popularity. Since the company has exclusive patent rights on tirzepatide, there are no generic versions. The FDA added tirzepatide medications to the shortage list, which allowed other companies to use compounding pharmacies to create medication with tirzepatide to meet demand. 

Recently, the FDA announced that the tirzepatide supply is now back on track, which should mean your prescription can be filled. This move also means that compounded versions could not be produced legally. However, this statement is under reevaluation, as customers have reported continued delays and trouble filling their prescriptions. If you have trouble filling your prescription, reach out to your Noom Med clinician for advice and alternatives. 

What’s the difference between semaglutide and tirzepatide? 

Semaglutide and tirzepatide are popular medications used for diabetes management and weight management, both taken as once-weekly injections. While they share similarities, there are key differences:

How they work: Semaglutide (Ozempic^®/Wegovy^®) targets GLP-1 receptors to reduce appetite, slow digestion, and stabilize blood sugar. Tirzepatide (Mounjaro^®/Zepbound^®) targets both GLP-1 and GIP receptors, potentially enhancing weight loss and metabolic benefits.

Cost and coverage: Semaglutide costs between $900 and $1,350 per month, with limited insurance coverage for weight loss. Tirzepatide averages $1,000 monthly, with Mounjaro^® having broader insurance coverage for diabetes, while Zepbound^® is less likely to be covered.

Efficacy: Both have been effective in treating diabetes and helping people lose weight. Tirzepatide’s dual action may lead to greater weight loss for some patients.

Zepbound^® vs. Mounjaro^®: How much weight can I lose?

Both Zepbound^® and Mounjaro^® are highly effective for weight loss. Since they contain the same active ingredient, tirzepatide, they work the same way to help you lose weight. 

How much can you expect to lose? At the highest dose (15 milligrams weekly), people using tirzepatide lost an average of 21% of their body weight over 72 weeks. Your results will vary depending on how you change your diet and your exercise level. 

The bottom line: Both Zepbound^® and Mounjaro^® are effective options for achieving significant weight loss. The best way to maximize your weight loss while taking these medications is to incorporate good eating and exercise habits into your lifestyle. 

How to maximize weight loss with Zepbound^® and Mounjaro^®

In order to really get the most out of your GLP-1 medication, it’s important to make sustainable lifestyle choices. These healthy habits will amplify the weight loss you can experience while taking the medication and help you keep the weight off after stopping your medication. Noom can help with targeted tools and guidance that will help you make the right changes for you and your goals. Here are a few things you can do to maximize your weight loss on tirzepatide:

• Eat more protein: Incorporate lean protein to preserve muscle mass and support metabolism during weight loss. Pair with whole grains, healthy fats, and colorful fruits and vegetables to meet nutritional needs. Noom’s food color system and GLP-1 Companion can be used to identify nourishing options.
• Build muscle and burn fat through exercise: Incorporate resistance training like weightlifting or bodyweight exercises to prevent muscle loss. Add cardio activities such as walking, swimming, or cycling to maintain metabolism. Explore Noom’s library of workouts to find exercises that fit your level and preferences. The Noom GLP-1 Companion also has a “Muscle Defense” library that contains exercises specifically designed to help prevent muscle loss while taking a GLP-1 medication.
• Track your progress: Use Noom’s meal tracker to monitor protein intake and ensure a balanced diet that aligns with weight loss goals. You can even track your water intake to ensure you’re staying hydrated. Use Noom Body Scan every two weeks to track changes in body composition to prevent muscle loss.
• Join a Noom community: Connect with others on similar health journeys through Noom’s supportive communities tailored to diverse goals and interests. These communities can help keep you motivated while also allowing you to troubleshoot any hurdles with others who might be facing the same challenges.

Zepbound^® vs. Mounjaro^®: Safety considerations

Both Zepbound^® and Mounjaro^® contain the same active ingredient, tirzepatide, which means their safety profiles and side effects are the same. Understanding the potential side effects can help you use these medications safely.

Are there people who shouldn’t take tirzepatide?

While tirzepatide is highly effective for managing diabetes and supporting weight loss, it isn’t right for everyone. If you have the following conditions, you shouldn’t take medications with tirzepatide:

• History of medullary thyroid cancer or MEN2 syndrome: Individuals with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2) should not take tirzepatide due to an increased risk of thyroid tumors.
• Severe gastrointestinal issues: Those with a history of severe gastrointestinal diseases, such as gastroparesis, should avoid tirzepatide as it can slow digestion further and worsen symptoms.
• Allergic reactions: Anyone with a known allergy to tirzepatide or its ingredients should not use medications containing it.
• Are pregnant, plan to become pregnant, or are breastfeeding: Tirzepatide has not been thoroughly studied in pregnant or breastfeeding people.
• Pancreatitis risk: People with a history of pancreatitis should not use tirzepatide, as GLP-1-based therapies may increase the risk of recurrence.
• Severe kidney or liver disease: Those with significant renal or hepatic impairment should discuss the risks with their doctor before starting tirzepatide.
• Certain medication interactions: Tirzepatide may interact with other medications.

Careful consideration of medical history and potential risks is crucial before starting tirzepatide to ensure safe and effective use. 

What are the most common side effects?

Many people experience mild side effects when starting Zepbound^® or Mounjaro^®. These are usually temporary and decrease as your body adjusts to the medication. Common side effects include:

• Nausea
• Diarrhea
• Vomiting
• Constipation
• Stomach pain

To manage these side effects, avoid foods that can worsen symptoms, such as sugary drinks, fried foods, or gas-forming vegetables. Tools like Noom’s GLP-1 Companion can guide you in making better food choices to minimize discomfort.

What are some severe side effects and warnings associated with tirzepatide?

While rare, serious side effects can occur with both Zepbound^® and Mounjaro^®. If you notice any of the following symptoms, seek medical attention immediately:

• Pancreatitis: Be alert for persistent stomach pain, especially if it radiates to your back.
• Allergic reactions: Symptoms include swelling of the face, lips, tongue, or throat; difficulty breathing or swallowing; severe rash or itching; dizziness; or a rapid heartbeat.
• Vision changes: Get any sudden vision changes checked immediately.
• Low blood sugar (hypoglycemia): If you have diabetes and use medications like insulin or other blood sugar-lowering drugs, watch for symptoms like dizziness, shakiness, sweating, or confusion.
• Kidney problems: Symptoms like swelling, fatigue, shortness of breath, or changes in urination could signal kidney issues, especially if dehydration occurs from nausea, vomiting, or diarrhea.
• Thyroid tumors: Watch for lumps or swelling in your neck, hoarseness, difficulty swallowing, or shortness of breath. Animal studies have shown a potential link between tirzepatide and thyroid tumors, but these types of tumors haven’t been reported in people.
• Depression or suicidal thoughts: If you notice new or worsening mental health symptoms, seek help immediately.

Both Zepbound^® and Mounjaro^® are highly effective medications, but understanding and monitoring potential side effects is essential. Consult your clinician if you experience any symptoms or have concerns. 

Zepbound^® vs. Mounjaro^®: Making the best choice

Zepbound^® and Mounjaro^® are essentially the same medication, both containing the active ingredient tirzepatide and functioning in identical ways to target GLP-1 and GIP hormones for weight management and diabetes treatment. The primary distinction lies in their FDA-approved uses, with Zepbound^® specifically approved for weight loss and Mounjaro^® for type 2 diabetes, though both can lead to significant weight loss. Their similar efficacy, safety profiles, and cost make the choice between them dependent on your individual health goals, insurance coverage, and availability. Ultimately, the decision should be guided by a healthcare provider, who can help determine the best option for your unique needs.

To get the most out of both of these medications, pairing them with healthy habits is key. If you qualify for Noom Med, your clinician can help you decide which is right for you and help you build a program to guide you on your weight loss journey. You’ll get personalized coaching, diet and exercise guidance, a vibrant community, and more. Plus, if your insurance doesn’t cover either medication, your clinician can decide if another medication or compounded semaglutide is available through alternatives like Noom GLP-1^Rx if access to branded options is a challenge. 

*Compounded semaglutide available on the Noom platform is produced in an FDA-registered facility but not reviewed by the FDA for safety, efficacy, or quality.

Note: Ozempic^® and Mounjaro^® are not FDA-approved to treat obesity or for weight loss.