What you’ll learn:

• Rybelsus is the first GLP-1 medication that can be taken by mouth. 
• Like Ozempic, Rybelsus is FDA-approved to treat type 2 diabetes but can be prescribed off-label for weight loss.
• Even though Rybelsus is an oral medication, it might not be more convenient than an injectable medication.

We all know that needles aren’t everyone’s cup of tea. If you’re one of those people who cringe at the thought of injections but are also interested in the benefits of GLP-1 medications like Ozempic, you’re in luck! It now comes in pill form and is called Rybelsus.

You take Rybelsus once a day, and it has the same active ingredient as Ozempic (semaglutide). While Rybelsus was approved in 2019 specifically for managing type 2 diabetes, it’s increasingly being prescribed off-label for weight loss, just like Ozempic.

So, if you’re tired of yo-yo dieting and looking for a solution that doesn’t involve painful injections, keep reading. We’ll explore how Rybelsus works and how Noom can help support your weight loss goals. 

What is Rybelsus and how does it work for weight loss?

As we said, Rybelsus is the first FDA-approved oral medication containing semaglutide. This was a major turning point for people with diabetes and weight management, opening up new possibilities for treatment.

But how does it work? The semaglutide in Rybelsus works by mimicking a hormone called GLP-1, a natural regulator of blood sugar and appetite. Taking Rybelsus can do a few things that can help you lose weight:

• Hits the “pause” button on your stomach: Rybelsus slows down how quickly your stomach empties, which means you feel fuller for longer and are less likely to overeat.
• Gives your insulin a boost: Rybelsus can normalize insulin levels, which will help balance your blood sugar.
• Puts the brakes on glucagon: This hormone normally signals your liver to release stored sugar, but Rybelsus helps to keep those sugar levels steady.

This unique combination of effects can lead to significant weight loss. Plus, no needles are necessary.

How is Rybelsus taken?

Take Rybelsus first thing every morning, following the same routine each time. You should swallow one pill whole—don’t split, crush, or chew it—with a small sip of water (no more than 4 ounces) on an empty stomach. 

How effective is Rybelsus for weight loss?

In a recent study, people taking Rybelsus lost an average of five to eight pounds in six months, depending on the dosage. That’s a pretty big difference compared to the average of three pounds lost by those taking a placebo.

Of course, everyone’s body is different. You could lose more or less weight depending on factors like your starting weight, lifestyle habits, and the dose you’re prescribed. Rybelsus is a helpful tool, but it’s not a magic solution. Combining Rybelsus with a healthy diet and regular exercise will supercharge your results and set you on the path to success. 

What makes Rybelsus different from Ozempic and Wegovy?

While all three share the same active ingredient, each one has its unique perks. The most obvious is that Rybelsus is taken as a daily pill, and Ozempic and Wegovy are administered through weekly injections. Wegovy alone is FDA-approved for weight loss.

You might notice Rybelsus contains a lot more semaglutide than Ozempic and Wegovy. This is because taking semaglutide orally isn’t as efficient as injecting it. Your body absorbs less of the medication through your digestive system, so a higher dose is needed to achieve the same results. Despite the differences in dose and administration, the side effects are similar.

But enough talk! Let’s compare these medications side-by-side in a handy table so you can easily see the differences:

Feature	Rybelsus	Ozempic	Wegovy
How it’s taken	A tablet is taken by mouth once a day in the morning.	A pre-filled pen that is injected under the skin (subcutaneously) once weekly.	Same as Ozempic.
Primary uses	Type 2 diabetes (FDA-approved), weight loss (off-label)	Type 2 diabetes (FDA-approved), weight loss (off-label)	FDA-approved for weight loss
Dosage	3, 7, or 14 mg daily	0.25, 0.5, or 1 mg weekly (up to 2 mg for diabetes)	0.25, 0.5, 1, 1.7, or 2.4 mg weekly
Cost	$969/month	$969/month	$1,350/month

Is Rybelsus more convenient than Ozempic or Wegovy?

While Rybelsus eliminates the need for injections, that doesn’t necessarily make it more convenient than a once-weekly injection. Timing is key for this oral medication. You’ll need to wait a full 30 minutes after taking it before you can eat, drink anything else (yes, even your morning coffee!), or take any other medications. This allows Rybelsus to work its best. After that 30-minute wait, you can have your breakfast and take your other medications. Take Rybelsus at the same time each day to maximize its effectiveness.

If you’re the type who likes to get up and go, this might seem like a bit of a hassle compared to the weekly injections of Ozempic or Wegovy. With those, you simply inject once a week and don’t need to worry about an empty stomach or timing restrictions. Ultimately, the most convenient option for you will depend on your personal preferences and lifestyle.

What does Rybelsus cost?

Now, let’s talk about the elephant in the room—the cost. While the medication’s potential weight loss benefits are appealing, the price tag can be a concern for many. As you can see above, both Rybelsus and Ozempic have similar price points. Wegovy is the priciest option. 

How much Rybelsus will actually cost you per month can vary depending on several factors, including insurance coverage, pharmacy location, and available discounts. Let’s explore the typical costs associated with Rybelsus and some strategies to make it more affordable.

Will insurance cover Rybelsus?

Your insurance company might cover some of the cost of Rybelsus if it’s used to treat diabetes. However, coverage and copayments vary widely between insurance plans. 

How can Noom Med help?

Noom Med can help you navigate the complexities of GLP-1 medications. If you qualify, Noom Med will connect you with a qualified clinician who will assist you in finding the right medication. They will discuss options and explore the costs and potential insurance coverage associated with each.

Rybelsus side effects and safety considerations

Like Ozempic and Wegovy, the most common side effects when starting Rybelsus are often stomach-related. Occasionally, people will experience serious issues. Your entire health history should be discussed with your doctor before you begin treatment.  

What are the common side effects of taking Rybelsus?

Rybelsus, like all medications, can cause side effects. Common side effects include:

• Nausea or vomiting
• Abdominal pain or discomfort
• Changes in bowel movements, such as constipation or diarrhea
• Dizziness or headaches
• Fatigue

These side effects are generally mild to moderate and often improve as your body adjusts to the medication. However, if you experience persistent or severe side effects, consult your healthcare provider. They can offer guidance on managing these effects or adjusting your treatment plan.

For the most up-to-date and comprehensive information about Rybelsus side effects, including less common reactions, refer to the official Rybelsus website or talk to your doctor.

How can Noom help manage Rybelsus’s side effects?

Managing side effects from medications like Rybelsus can be challenging, but Noom’s GLP-1 Companion offers tailored support to help you maximize the benefits of your treatment and minimize any discomfort. Here’s how:

• Guidance and support: Get step-by-step guidance and tools to help manage common challenges associated with GLP-1 medications. 
• Nutrition and exercise tips: Track your protein intake and get targeted exercise videos to minimize muscle loss while building strength.
• Education: Empower yourself with knowledge and tools to make sustainable changes to your eating and lifestyle habits.

By leveraging Noom’s resources, you’re setting yourself up for a more comfortable and successful weight loss journey.

Can Rybelsus be used alongside other medications?

Semaglutide has about 250 known drug interactions, so you will need to talk to your doctor about all the medication you are taking. Rybelsus, in particular, could interact with medications, including:

• Other diabetes medications: Taking Rybelsus with insulin, sulfonylurea medications (Glyburide, Glimepiride, Glipizide), or meglitinides (repaglinide and nateglinide) can increase the probability of low blood sugar (hypoglycemia). Discuss all other diabetes medications with your doctor before beginning Rybelsus. 
• Levothyroxine (Synthroid): Rybelsus can delay gastric emptying, potentially affecting the absorption of this important thyroid medication.

Will Rybelsus affect my birth control medication?

Research is still ongoing to understand the potential interactions between GLP-1 weight loss medications like Rybelsus and oral contraceptives. There’s a possibility that Rybelsus could reduce the effectiveness of birth control. Discuss this with your doctor before beginning treatment.

What are the serious effects and warnings associated with Rybelsus?

Now that you know the common side effects, let’s talk about the rare but more serious side effects of Rybelsus. These need immediate medical attention:

• Pancreatitis: Be alert to nausea, vomiting, and severe abdominal pain that may radiate to the back. 
• Allergic reactions: Keep an eye out for a rash, itching, swelling (especially of the face, tongue, and throat), severe dizziness, and trouble breathing.
• Hypoglycemia (low blood sugar): Signs include dizziness, sweating, confusion, headache, and blurred vision. This will likely only be an issue if you are on insulin or other diabetic medications.
• Kidney problems: Be alert for changes in urination, swelling in feet or ankles, and fatigue.
• Gallbladder disease: Any sudden abdominal pain, fever, or yellowing of skin/eyes should be evaluated.
• Thyroid tumors: Signs include a lump in the neck, difficulty swallowing, hoarseness, and shortness of breath. Note: No proof of the connection has been found in people.

For the most up-to-date and comprehensive list of side effects, be sure to check the official Rybelsus website. 

Are there any health issues that might make Rybelsus unsuitable for me?

You might be wondering, “Is Rybelsus right for me?” While it’s a promising medication, certain health conditions may require extra caution or make you unsuitable for Rybelsus. Here are some key health issues to be aware of:

• Pregnancy or planning to become pregnant: Discontinue Rybelsus at least two months before trying to become pregnant due to potential risks to the fetus. If you become pregnant, inform your doctor immediately.
• History of pancreatitis: You should not take Rybelsus if you’ve ever had pancreatitis.
• Thyroid conditions: Those with a personal or family history of medullary thyroid cancer should avoid Rybelsus.
• Severe gastrointestinal disease: Certain stomach issues can be worsened by Rybelsus.
• Kidney problems: Rybelsus may affect kidney function.

Your healthcare provider is best equipped to evaluate your health status and determine if Rybelsus is suitable for you. Always provide a complete medical history and list of current medications to ensure safe and effective treatment.

How Noom can help

Rybelsus can be a valuable addition to your path toward better health, especially when combined with the right support. While Rybelsus tackles blood sugar and weight, Noom’s approach helps you build lasting healthy habits for long-term success.

If you qualify, Noom Med can be a great way to enhance your results. It’s like having a personalized health team in your pocket:

• One-on-one consultations with clinicians: Get expert guidance and support tailored to your unique needs and goals.
• Access to a dedicated care team: Receive ongoing support and motivation from healthcare professionals throughout your journey.
• Prescription weight loss medications: Explore options like Rybelsus to complement your efforts.

If you are already taking Rybelsus, our GLP-1 Companion program is here to empower you. It’s packed with resources to help you thrive while taking a GLP-1 medication:

• Expert nutrition guidance: Make informed food choices that complement your medication.
• Engaging fitness lessons: Discover enjoyable ways to stay active and support your weight loss goals.
• Muscle-preserving tools: Keep your strength up and minimize muscle loss with protein tracking and targeted exercise recommendations.

Noom understands that lasting weight loss is about more than just numbers on the scale. It’s about fostering a healthy relationship with your body and mind while creating sustainable habits that support your overall well-being. By combining Rybelsus with Noom’s evidence-based strategies, you’re not just focused on weight loss but embracing a comprehensive approach to health. 

Note: Rybelsus and Ozempic are not FDA-approved to treat obesity or for weight loss.