Saxenda® vs. Ozempic® for weight loss: Which one works best in 2025?

What you’ll learn:   

• Ozempic^® and Saxenda^® are GLP-1 medications that have different active ingredients and different approved uses, but both are prescribed for weight loss.
• Saxenda^® is FDA-approved for weight loss, while Ozempic^® is approved for type 2 diabetes and is often prescribed off-label for weight management.
• People tend to lose more weight with Ozempic than with Saxenda, though individual results vary.

If you’re looking into your weight loss medication options, it’s hard not to hear about Ozempic^®. This GLP-1 receptor agonist medication has revolutionized weight management, even though it’s FDA-approved to treat type 2 diabetes. One you might not have heard of is Saxenda^®. This is also a GLP-1 medication that works similarly to Ozempic, but it’s FDA-approved for weight loss. 

What’s the difference? Although both medications belong to the GLP-1 family, they have different active ingredients. Ozempic^® is made with semaglutide, while Saxenda is made with liraglutide. Another big difference is that Saxenda is a daily injected medication while Ozempic is injected only once per week. They also have different effectiveness, costs, and insurance coverage options. These are all important differences to think about before you choose one or the other.

Looking to understand which might work better for you? We’ll break down everything you need to know so you can make an informed decision with your healthcare provider about the best option for your weight loss goals.

Ozempic^® vs. Saxenda^®: How do they work?

Both medications work by mimicking the body’s natural GLP-1 hormone, which affects different areas of the body to:

• Reduce appetite 
• Slow digestion, so you feel full longer
• Regulate blood sugar levels 

Despite working in a similar way, Ozempic^® and Saxenda^® have some important differences. 

Ozempic^® vs. Saxenda^®: The differences

Ozempic^® and Saxenda^® have several differences that may impact which medication will be right for you. 

Let’s break them down:

Approved uses

An approved use means the FDA has reviewed a medication and confirmed it is safe and effective for treating a specific condition. When a drug receives FDA approval for a particular use, it can be marketed and prescribed for that purpose. Insurance is also more likely to cover it, though coverage depends on your specific plan.

• Saxenda^® is FDA-approved for weight management for people with a BMI of 30 or more or 27 or higher with a weight-related medical issue, like high blood pressure. Although Saxenda is FDA-approved for weight loss, insurance coverage isn’t likely, as many health plans exclude weight loss medications entirely. 
• Ozempic^® is FDA-approved for type 2 diabetes, but doctors can prescribe it off-label for weight loss under the same BMI requirements as Saxenda. It may be covered by insurance for diabetes but rarely for weight loss. 

Dosing and administration

One of the biggest differences between Saxenda^® and Ozempic^® is the need for how often they need to be injected. 

• Saxenda^® is a daily injection. You’ll start at 0.6 mg per day, and that will increase as needed and tolerated to 3.0 mg per day. 
• Ozempic^® is a weekly injection. Dosing starts at 0.25 mg per week and then increases as needed and tolerated. The maximum possible dose is 2.0 mg per week. 

Both medications are on a step-up dosing schedule, meaning the dose is increased gradually to help your body adjust and to minimize side effects. 

Pricing

Cost can be a major factor in choosing between these medications. The cost difference between Ozempic^® and Saxenda^® includes factors like insurance coverage, supply needs, and available savings programs. Insurance is unlikely to cover either medication for weight loss. 

• Saxenda^®: The list price is $1,349 per month. Since it is FDA-approved for weight management, some insurers may cover it, but most exclude weight loss drugs from their plans. 
• Ozempic^®: The list price is about $997 per month, regardless of dose. Here’s a complete breakdown of what Ozempic^® will cost you based on your insurance coverage.

Ozempic^® vs. Saxenda^®: The similarities

Despite their differences, Ozempic^® and Saxenda^® share several important characteristics. Here are the key features they share:

• Both are GLP-1 receptor agonists: They target GLP-1 receptors to help regulate appetite and digestion.
• Injectable medications: Both medications come as pre-filled injector pens that make it easy to give yourself injections. Most people report little to no pain.
• They have similar side effects: Both may cause gastrointestinal issues, which typically improve over time.
• Manufactured by Novo Nordisk: Both Ozempic^® and Saxenda^® are manufactured by the same company. It also produces the semaglutide-based medications Wegovy^® and Rybelsus^® and the liraglutide-based medication Victoza^®.

Can you switch between Ozempic^® and Saxenda^®?

While it’s possible to switch between Ozempic^® and Saxenda^®, this decision should always be made under the guidance of your healthcare provider. Before making any changes, your physician will evaluate your weight management progress, tolerance to the current medication, and overall wellness goals. 

The key difference to consider is the shift from Ozempic^®‘s once-weekly injections to Saxenda’s^® daily dosing schedule. Also, during the transition, you might notice gastrointestinal side effects (nausea, stomach ache, etc.), but these should only be temporary.

Your doctor might recommend switching based on several factors, including medication costs, insurance dynamics, or your personal schedule preferences, and will create a tailored plan to ensure a smooth transition between medications.

Ozempic^® vs. Saxenda^®: Which is better for weight loss?

Both Saxenda^® and Ozempic^® can help you lose weight, but one may do it better than the other. Research has found that people using semaglutide lost an average of 15% of their body weight over 68 weeks, while a study showed that people taking liraglutide lost 5 to 10% of their body weight in 56 weeks. 

But how much weight you can lose isn’t the only thing to consider when deciding which to use for weight loss. The dosing schedules and accessibility of both medications are also important. Saxenda^®’s daily injections can be a barrier for some people. Also, you will need to consider which medication you can afford since both are unlikely to be covered by insurance for weight loss. 

Ultimately, the “better” choice depends on your personal circumstances—including your weight loss goals, daily routine, budget, and insurance coverage. A healthcare provider can help determine the most practical and effective option based on your specific situation and needs.

How much weight can you lose on Ozempic^® vs. Saxenda^®?

As we noted above, people using semaglutide lost an average of 15% of their body weight over 68 weeks, while people taking liraglutide lost 5 to 10% of their body weight. It’s important to highlight that these are averages, which means some people will lose even more. 

In a 16-month study of semaglutide, nearly 87% lost at least 5%, and over 50% lost 15% or more.  In comparison, in a clinical study of liraglutide, 85% of adults lost weight, with an average weight loss range of 5% to 10% of their starting body weight. 

Both trials integrated lifestyle modifications, highlighting that these medications work best when combined with healthy eating and regular exercise. Results will vary depending on the extent of lifestyle changes.

How long does it take to see results?

With both Ozempic^® and Saxenda^®, you might notice initial changes in appetite and eating habits within the first few weeks of treatment. However, the weight loss timeline and results differ between the medications.

• Ozempic: Studies show that people on semaglutide continue to lose weight gradually, though it may slow down or level off around 60 weeks, sometimes called the ‘Ozempic plateau.’ Sticking with treatment—and making healthy lifestyle changes—can help you continue to see progress.
• Liraglutide: Clinical trials of Saxenda^® show that results were sometimes seen as early as the first few weeks of treatment. Many people see a loss of up to 4% of body weight by 16 weeks. It usually takes about 6 months to reach the maximum weight loss point.

Studies consistently show that those who combine their medication with a reduced-calorie diet and regular physical activity achieve significantly better outcomes than those who rely on medication alone.

Who can take Ozempic^® or Saxenda^® for weight loss?

While both medications can support weight loss, they have different FDA approvals and eligibility criteria.

Saxenda^® is FDA-approved for weight management in adults with a BMI of 30 or higher or a BMI of 27 or higher who have at least one weight-related health condition (such as high blood pressure, high cholesterol, or type 2 diabetes). It can also be prescribed to 12-17-year-olds in certain circumstances.

Ozempic^® is FDA-approved for treating type 2 diabetes. However, doctors may prescribe it off-label for weight loss in adults with a BMI of 30 or higher or with a BMI of 27 or higher who have weight-related health conditions. Unlike Saxenda^®, Ozempic^® is not approved for weight management in adolescents.

In both cases, your healthcare provider will evaluate your complete medical history, current medications, and specific health needs before determining if either medication is appropriate for you.

Who shouldn’t take Ozempic^® or Saxenda^®?

These medications aren’t right for everyone and can be harmful to some groups of people. You should not use either medication if you:

• Have a personal or family history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN 2)
• Are allergic to semaglutide (Ozempic^®) or liraglutide (Saxenda^®) or any of their ingredients
• Have a history of pancreatitis
• Have severe gastrointestinal issues, such as gastroparesis (delayed stomach emptying)
• Are pregnant, planning to become pregnant, or breastfeeding
• Have a history of suicidal thoughts or behaviors (specific to Saxenda^®)
• Have a history of diabetic retinopathy (specific to Ozempic^®)

For more detailed safety information, visit our Ozempic^® safety page or the official Saxenda^® safety page.

If you take Saxenda^® or Ozempic^® to lose weight, will you need to keep taking them forever?

It depends. While both medications are approved for long-term use, the duration of treatment varies based on individual health goals and medical recommendations. These GLP-1 medications work by controlling appetite and metabolism, but they don’t permanently alter how your body regulates weight. Some people may need to continue on a maintenance dose long-term to sustain their results, while others successfully transition off the medication after reaching their goals.

The key to maintaining weight loss with either medication is developing sustainable lifestyle habits while taking them. Programs like Noom can help you build lasting behavioral changes around eating and exercise, making it easier to maintain your progress whether you stay on the medication or eventually stop.

If you stop taking Ozempic^® or Saxenda^®, weight regain is possible as appetite and hunger signals return to pre-medication levels. Here’s what you need to know:

• Ozempic^® often requires a gradual dose reduction (tapering) to minimize potential side effects. A study found that people who tapered off semaglutide maintained a stable weight for 26 weeks.
• Saxenda^® typically doesn’t require tapering, but stopping abruptly may increase hunger.
• Most people maintain better results if they’ve established consistent healthy habits while on the medication.
• You may be able to restart either medication if needed, but this should always be done under medical supervision.

The most successful long-term outcomes typically come from combining these medications with permanent lifestyle changes rather than relying solely on the medication for weight management.

Saxenda^® vs. Ozempic^®: What do they cost?

Insurance coverage for both Saxenda^® and Ozempic^® varies significantly depending on your insurance plan, but coverage specifically for weight loss is uncommon.

• Saxenda^®: The list price is approximately $1,349 per month. While some private insurance plans may cover it for weight management since it’s FDA-approved for this purpose, many exclude weight loss medications entirely.  Get the full details on Saxenda pricing and insurance coverage. 
• Ozempic^®: Without insurance, Ozempic^® costs about $997 per month. Insurance coverage is more likely when prescribed for type 2 diabetes but is usually denied for off-label weight loss use. Get the full details on Ozempic^® pricing and insurance coverage. 

Since insurance policies frequently change, check directly with your provider for the most current coverage information. 

Does Medicare cover Ozempic^® or Saxenda^®? 

Medicare Part D may cover Ozempic^® when prescribed for type 2 diabetes, but not for weight loss. Saxenda^® is rarely covered as Medicare typically excludes weight loss medications. Also for consideration, starting in 2025, the Inflation Reduction Act will cap annual out-of-pocket drug costs at $2,000 for Medicare Part D enrollees, which could lower expenses.

Ozempic^® vs. Saxenda^®: Side effects

Since Ozempic^® and Saxenda^® are both GLP-1 medications, they share many similar side effects, though their frequency and severity can differ.

Common side effects

Most people experience mild to moderate side effects, especially when starting the medication or adjusting to a higher dose. These include:

• Nausea
• Vomiting
• Diarrhea or constipation
• Stomach pain 
• Fatigue

Here are also some tips on how to manage the side effects of Ozempic^® and GLP-1 medications in general.

Serious side effects and warnings

Some serious but rare side effects are possible with Ozempic^® and Saxenda^®. Both have FDA warnings for the potential risk of thyroid C-cell tumors, including medullary thyroid carcinoma (MTC). This risk has only been observed in animal studies. Do not take these medications if you or a family member has a history of MTC or multiple endocrine neoplasia syndrome type 2 (MEN 2).

Here are some other conditions to watch out for that require immediate medical help if experienced:

• Pancreatitis: Symptoms include severe abdominal pain that may spread to your back, with or without vomiting. Learn more about the risk of pancreatitis with Ozempic^®.
• Vision changes: Get immediate medical attention if you have sudden vision changes.
• Low blood sugar (hypoglycemia): Symptoms include dizziness, shakiness, blurred vision, fast heartbeat, and jittery feelings. It is more common in people taking diabetes medications. Read about Ozempic^® and hypoglycemia here.
• Kidney problems: Dehydration from diarrhea, nausea, or vomiting can worsen kidney function. Go to the ER if you have reduced urination, swelling in the ankles or legs, fatigue, or shortness of breath.
• Gallbladder problems: Watch for upper abdominal pain, fever, jaundice, or clay-colored stools, which could indicate gallbladder issues.
• Allergic reaction: Symptoms include swelling of the face, lips, tongue, or throat, difficulty breathing or swallowing, and a rapid heartbeat. Seek immediate emergency care if you suspect a reaction.

Other conditions associated with Ozempic^® 

While Ozempic^® and Saxenda^® have well-documented side effects, some lesser-known effects have been reported or observed in clinical practice with GLP-1 medications. These are not officially listed side effects, but you may experience:

• Muscle loss (sarcopenia) – Rapid weight loss can lead to muscle loss, especially if protein intake is low or strength training isn’t part of a routine. Preserving muscle is key for metabolism and overall health.
• “Ozempic face” – Significant weight loss can reduce facial fat, producing a hollowed or aged appearance. This is common with any rapid weight loss, not just GLP-1 medications.
• GLP-1 hair loss – Some people experience temporary hair thinning or increased shedding (alopecia) while on GLP-1 medications. This is likely due to rapid weight loss. In most cases, hair regrows once weight stabilizes.

Ozempic^® vs. Saxenda^®: Which one is safer?

Both medications have similar safety profiles and are generally well-tolerated when used as prescribed. Your healthcare provider will typically start with a low dose and gradually increase it to minimize side effects.

To reduce side effects with either medication:

• Follow the prescribed dosing schedule carefully.
• Stay well-hydrated. GLP-1 medications can reduce thirst alongside hunger.
• Maintain adequate protein intake and exercise regularly to preserve muscle mass.
• Report any concerning symptoms to your healthcare provider promptly.

Remember that monitoring side effects, staying active, and following a balanced diet can help improve your experience with either medication.

Saxenda^® vs. Ozempic^®: Which is right for me?

Deciding between Saxenda^® and Ozempic^® depends on several factors. While the amount of weight loss potential is important, you have things to consider beyond just effectiveness. Let’s break down the key considerations:

• Insurance and cost: Saxenda^® may have better coverage for weight loss since it’s FDA-approved for this purpose, though this is still spotty. Ozempic^® is less expensive than Saxenda^® without insurance and is more likely to be covered if you have type 2 diabetes. Always check with your insurance for details on your specific plan.
• Availability: Semaglutide has been removed from the FDA shortage list, and all doses are listed as available. Liraglutide is still on the FDA shortage list. The generic medication is listed as “available,” while Saxenda and Victoza are listed as “limited availability.” Since these are both popular medications, it’s a good idea to check with your pharmacy in advance to confirm stock. If you have any trouble finding Ozempic in stock, here are some tips for locating it.
• Dosing schedule: With Ozempic^®, you’ll give yourself weekly injections, while with Saxenda^®, you’ll give yourself daily injections.
• Health considerations: While both medications can help you lose weight, Ozempic^® can be more effective. 
• Side effects: Since Ozempic^® and Saxenda^® are both GLP-1 medications, they have similar side effects, though how you specifically react to them will vary.

The best choice ultimately depends on your specific situation, including your health history, insurance coverage, budget, and lifestyle preferences. Discussing these factors with your healthcare provider can help determine the one that’s best for you. If you qualify for Noom Med, you’ll be connected with a clinician who can go through all of the elements and find the right medication for you. (It might even be a different one!)

Other weight loss medications you can try

There are several alternatives to Ozempic® and Saxenda® available, each with varying costs, dosing schedules, and effectiveness. These include other GLP-1 receptor agonists and non-GLP-1 options. Let’s take a look:

Other semaglutide medications

Two other medications contain semaglutide, the same active ingredient as Ozempic^®. They are both made by Novo Nordisk.

• Wegovy^® – Unlike Ozempic^®, Wegovy is FDA-approved for weight loss. It can also be used to treat and prevent heart disease. It is also taken as a once-weekly injection. Its list cost is similar to Saxenda^® at $1,349 for a month’s supply.
• Rybelsus^® – Rybelsus is the only GLP-1 pill currently on the market. It’s FDA-approved for managing type 2 diabetes and is sometimes prescribed off-label for weight loss. Its list price without insurance is approximately $998 per month.

Compounded semaglutide through Noom GLP-1^Rx

You can also explore compounded semaglutide via Noom GLP-1^Rx. It contains the same active ingredient as Ozempic and Wegovy at a potentially more affordable price. If you qualify for Noom Med, a clinician can determine whether it is a good option. If prescribed, it will cost $149 for the first month, with medication included. You’ll get access to a clinician to answer your questions and develop a weight loss plan. You can also access all of Noom’s tools, trackers, and fitness programs. Plus, you’ll be part of a community that will motivate you on your weight loss journey.

Other liraglutide medications

Besides Saxenda^®, there are two other liraglutide medications to consider.

• Victoza^® – Victoza^® is FDA-approved for diabetes management and is sometimes prescribed off-label for weight loss. Without insurance, the cost ranges from $800 to $1,400 per month. It’s also made by Novo Nordisk.
• Generic liraglutide – TEVA Pharmaceuticals makes generic liraglutide, which is FDA-approved to manage type 2 diabetes. It costs around $470 for two pens and $704 for three pens.

Tirzepatide medications 

Tirzepatide works differently from semaglutide and liraglutide by targeting two hormone receptors (GLP-1 and GIP) instead of just GLP-1. This dual action can lead to more significant weight loss for some people, with clinical trials showing an average weight loss of 21% of body weight in 16 months with tirzepatide medications. There are two tirzepatide options to consider.

• Zepbound^® – Zepbound^® is FDA-approved specifically for weight management and treatment of sleep apnea. Without insurance, it costs around $1,086 per month.
• Mounjaro^® – Mounjaro^® contains the same active ingredient as Zepbound^® but is FDA-approved for type 2 diabetes, though it’s often prescribed off-label for weight loss. It costs approximately $1,080 per month without insurance. 

Dulaglutide medication

Dulaglutide, sold under the brand name Trulicity^®, is another once-weekly injectable GLP-1 medication. While it functions similarly to Ozempic^®, it interacts with GLP-1 receptors in a slightly different way. Trulicity^® is FDA-approved for managing type 2 diabetes but is sometimes prescribed off-label for weight loss. Without insurance, its list price is approximately $987 per month.

Other weight loss medications

Other medications may be an option if GLP-1 medications aren’t available or covered. Their effectiveness varies from person to person.

• Metformin – Metformin is typically prescribed to treat type 2 diabetes but is sometimes used off-label for weight loss.
• Orlistat – Orlistat blocks fat absorption and is taken three times daily with meals. The cost ranges from $50 to $800 per month without insurance.
• Phentermine – Phentermine is a short-term appetite suppressant taken once daily. Prices typically range from $27 to $100 per month without insurance.
• Diethylpropion – This medication is also used as an appetite suppressant and is taken one to three times daily. Costs range from $40 to $85 per month without insurance.
• Naltrexone and bupropion (Contrave)– This combo drug helps reduce appetite and cravings in some people. Through the CurAccess™ Patient Support Program, Contrave^®  costs $99 per month with free shipping. Without this program, prices can range from $600 to $800 per month, depending on insurance.

Ozempic^® and Saxenda^®: Choosing a weight loss medication

Deciding between Ozempic^® and Saxenda^® involves more than just comparing their weight loss potential. While Ozempic^® typically shows greater average weight loss in clinical trials, factors like insurance coverage, dosing preference (weekly vs. daily), and medication availability often play the biggest roles in making this decision.

At the end of the day, the most effective medication is one you can consistently access, afford, and integrate into your lifestyle. Both medications work best when combined with sustainable habits—including mindful eating, regular physical activity, and lasting behavior changes.

 If you’re weighing your options, work with your healthcare provider to determine the best fit, considering both your medical needs and practical constraints. If you qualify for Noom Med, your clinician can prescribe medication, if needed, and help guide you through your weight management journey.

Compounded semaglutide available on the Noom platform is produced in an FDA-registered facility but not reviewed by the FDA for safety, efficacy, or quality.

Note: Ozempic^® is not FDA-approved to treat obesity or for weight loss.