What you’ll learn:

• ‘Ozempic® personality’ is a phrase people use to describe mood and behavior changes they experience while taking medications containing semaglutide. 
• These shifts may be linked to semaglutide’s influence on brain chemistry, potentially affecting emotions and how individuals express themselves. 
• If you notice any emotional changes while on Ozempic^®, consult your clinician to discuss these side effects and explore possible solutions.

Ozempic^®, a medication initially used to treat type 2 diabetes, has gained widespread attention for its remarkable off-label weight loss effects. But alongside its success stories, a growing number of people who take it are reporting a curious phenomenon they call ‘Ozempic personality.’ This term refers to noticeable shifts in mood and behavior, with some individuals experiencing unexpected mood swings, heightened anxiety, or even feelings of depression.

The active ingredient in Ozempic^®, semaglutide (also found in Wegovy^® and Rybelsus^®), is designed to regulate blood sugar and appetite. Reports suggest Ozempic^® and medications like it may also negatively influence emotions enough to impact how some people behave. While these changes are not universal, and many report positive results, the frequency of reports (mainly in people taking these medications for diabetes) has prompted the FDA to investigate.

At Noom, we believe in addressing the whole picture—your weight loss goals and overall well-being. Whether you love your Ozempic^® results or are navigating unexpected changes, we provide information, support, and guidance to help you feel your best.  So, if you aren’t feeling like yourself, let’s explore what’s going on and how we can support you.

Is ‘Ozempic personality’ a real side effect?

‘Ozempic® personality’ is not a recognized medical term or side effect of Ozempic^®. It’s a colloquial phrase, often used in the media or on social platforms, that describes the changes people report experiencing in mood and behavior while taking Ozempic^®. 

Mood changes are a recognized potential side effect of semaglutide medications. Wegovy^® (the semaglutide medication that is currently FDA-approved for weight loss) carries a warning about the potential for depression or suicidal thoughts. 

It is important to note that the FDA has not found an association between GLP-1 receptor agonist medications like Ozempic^® and Wegovy^® and mood changes, but it is continuing to investigate.

What is personality?

Changes in mood due to medication can affect how someone expresses themselves and interacts with others, which might be perceived as a shift in personality. However, these mood changes do not alter a person’s core personality.

Personality is the unique thinking, feeling, and behavior patterns that define a person. It influences how we interact with the world and remains consistent throughout life. Nevertheless, various factors, including life experiences, personal growth, and medical conditions, can change how personality is expressed.

Understanding Ozempic^® personality changes

With this background in mind, let’s explore the potential impact of Ozempic^® or semaglutide on brain chemistry. While many people experience positive changes from the medication and minor side effects, some report concerning shifts in mood and behavior. These unexpected but generally short-lived shifts have raised concerns and sparked curiosity about how Ozempic^® could affect the brain.

How could Ozempic® influence mood and behavior?

The semaglutide in Ozempic® mimics a hormone called GLP-1, which regulates hunger and blood sugar and plays a role in brain function. It’s believed that GLP-1 can impact dopamine, a neurotransmitter associated with motivation, reward, and emotional regulation.

While the exact causes are still under investigation, it’s plausible that changes in dopamine levels caused by Ozempic^® could contribute to shifts in mood and behavior. This dopamine connection could explain why some people experience increased anxiety, depression, or mood swings while taking the medication.

What kinds of changes do people report? 

A small percentage of people—less than 5% according to one analysis—who took semaglutide and other GLP-1s experience symptoms like:

• Signs of depression
• Increased anxiety and panic attacks
• Reduced ability to feel pleasure from activities they once enjoyed

These shifts can affect how people interact with others and experience daily life, which can be seen as a change in personality. The jury is also out on how long these feelings can last. Some reported the effects faded over time, while others experienced lasting changes. 

Are some people more likely to experience these changes?

It’s possible. Several factors may contribute to a person’s susceptibility to mood and behavior changes while taking Ozempic^®:

• History of mental health issues: People with pre-existing mental health conditions, such as anxiety or depression, may be more sensitive to the emotional effects of Ozempic^® or other GLP-1s.
• Rapid weight loss and lifestyle changes: Rapid weight loss often necessitates significant changes in eating habits and routines. These adjustments, coupled with the weight loss itself, can disrupt established coping mechanisms and trigger emotional shifts.
• Physical side effects: Nausea and vomiting, typical side effects of Ozempic^®, can contribute to feelings of isolation, difficulty concentrating, and further impact mood.

Remember, everyone’s experience with Ozempic^® is unique. While these reports are important, they don’t mean everyone will experience personality changes. It is always best to talk with a clinician about any concerns or changes you notice while taking Ozempic®.

Coping with Ozempic^® and mood changes

Experiencing mood shifts while taking Ozempic^® can be confusing. Here are some common questions and answers to help you navigate these changes:

How can I tell if my mood changes are from Ozempic^® or just common fluctuations?

Your mood can change as you deal with daily events, stress, sleep disruptions, and hormonal fluctuations. These are usually temporary and manageable.

Ozempic^®-related mood changes, on the other hand, could be more persistent or intense, and they may occur alongside other side effects of the medication.

Here are things to consider:

• Timing: Did the mood changes start or worsen after you began taking Ozempic^®?
• Severity: Are the changes more intense or longer-lasting than your usual mood fluctuations?
• Other symptoms: Are you experiencing any other side effects of Ozempic^®, like nausea, changes in appetite, or sleep disturbances?

If you notice sudden, intense, or lasting emotional changes after starting Ozempic^®, it’s important to talk to a mental health professional. They can provide the support and guidance you need to navigate these changes.

What should I do if I experience severe mood shifts on Ozempic^®?

If you’re feeling overwhelmed by mood changes or experiencing symptoms of depression or anxiety—reach out to your clinician or get immediate medical help right away. They can assess whether these changes are related to Ozempic^® and might suggest adjusting your dose or exploring alternative treatments. Remember, your mental health is just as important as your physical health.

Are there ways to cope with mood changes while taking Ozempic^®?

Yes, several strategies may help manage and cope with potential personality changes while taking Ozempic^®:

• Prioritize self-care: Maintaining a healthy lifestyle can help support your mental well-being. Here’s what you can do:
  • Get enough sleep: Aim for seven to eight hours per night to help regulate mood and energy levels.
  • Exercise regularly: Engage in physical activity you enjoy, as it can help reduce stress and boost mood.
  • Manage stress: Practice relaxation techniques like meditation, deep breathing, or yoga to manage stress and anxiety.
• Seek support: Talk to friends, family, or a therapist about your feelings. Joining a support group for people taking Ozempic^® or other weight-loss medications can also be helpful.
• Explore specialized programs: Noom’s GLP-1 Companion offers personalized guidance and support for individuals taking medications like Ozempic^®, including strategies for managing potential side effects and emotional challenges.

If your mood changes are severe, persistent, or interfering with your daily life, talk to your clinician or a mental health professional. They can help you assess the situation and recommend appropriate treatment options.

Can personality changes from Ozempic^® be reversed?

Personality changes that occur while taking Ozempic^® may be reversible, especially if they are linked to the medication. These changes could improve over time if the dosage is adjusted or the drug is discontinued under the guidance of a healthcare provider. It’s crucial to consult with your doctor if you notice significant mood or behavior changes, as they can help determine whether the medication is the cause and suggest appropriate adjustments or alternatives. 

Caring for physical and mental health with Noom

Ozempic^® can help you lose weight, but it can also have some confusing side effects. While some people who take Ozempic^® report changes in their mood and behavior, this should not be confused with lasting changes to your personality. The term ‘Ozempic personality’ is not a medically recognized condition but rather how some people describe the emotional changes they experience while taking the medication. 

It’s important to understand that these mood shifts can vary from person to person. Ongoing studies are investigating the potential link between Ozempic^® and emotional changes. If you have any concerns about side effects while taking Ozempic^®, always contact your clinician.

Noom understands that your health journey is unique and involves much more than weight loss. We offer comprehensive care that blends personalized solutions with support for your mental well-being so you can feel empowered to take charge of your health.

If you qualify, Noom Med will connect you with a qualified clinician to determine if Ozempic^® or another GLP-1 medication is for you. Then, they’ll help you create a personalized care plan and connect you with our expert team for guidance every step of the way. 

If you’re already taking Ozempic^® or another GLP-1, our GLP-1 Companion is here to help. It offers tips on managing side effects and nutrition to make the most of your medication. Plus, it includes guidance on which exercises to incorporate and ongoing support to ensure you feel your best.

Whether you’re just starting Ozempic^® or are already familiar with it, Noom is here to help you reach your goals and feel your best.

Note: Ozempic^® is not FDA-approved to treat obesity or for weight loss.