Kidney disease and Ozempic: What you need to know

What you’ll learn:

• Ozempic, known for managing diabetes and aiding weight loss, may also help slow down kidney disease.
• Clinical trials have shown that Ozempic can significantly reduce the risk of kidney complications in people with type 2 diabetes and chronic kidney disease.
• Ozempic’s benefits for kidney health may stem from better blood sugar control, reduced inflammation, and lower blood pressure.

While you’re probably familiar with Ozempic as a diabetes medication or as a popular off-label solution for weight loss, it could have other surprising benefits. Preliminary studies have suggested that semaglutide, the active ingredient in Ozempic, could potentially slow down kidney disease in people with diabetes. 

How can Ozempic help protect your kidneys? As a GLP-1 receptor agonist, Ozempic, and medications like it, work by mimicking a hormone called GLP-1. This action helps your body regulate blood sugar and reduce hunger, which can lead to weight loss. These benefits can also lead to better overall health, which could give some love to your kidneys! However, it’s important to note that these benefits only apply to kidney issues caused by diabetes and do not apply to individuals with chronic kidney disease due to other conditions like polycystic kidney disease.

Want to know more? If you qualify for Noom Med, we’ll connect you with a clinician who can find the right medication for your weight loss and health goals. We offer personalized guidance and support on your journey to better health, even if you’re living with kidney disease.

The impact of Ozempic on kidney function 

A major clinical trial found that Ozempic significantly reduced the risk of kidney complications, heart issues, and death in people with type 2 diabetes and chronic kidney disease. The results were so impressive that researchers stopped it early due to its success. Key findings included:

• A 24% lower risk of major kidney disease events and death related to kidney issues, and a 20% lower risk of death from any cause, compared to a placebo.
• The potential for delayed progression of kidney disease in people with type 2 diabetes.
• Reduced risk of kidney failure and death in people living with type 2 diabetes and chronic kidney disease.

These results are particularly important because about one in three adults living with diabetes also has chronic kidney disease. If this sounds like you, Ozempic could offer real hope for protecting your kidneys and managing your blood sugar.

Now, don’t get too excited just yet. First, talk with your doctor about whether Ozempic is a good fit for you. They’ll look at your overall health, medical history, and any other medications you’re taking to make sure it’s a safe and effective option before prescribing it. They will also keep a close eye on your kidney function while you’re on it.

How Ozempic works to protect kidneys

The exact ways semaglutide benefits your kidneys are still being studied, but research suggests a few key possibilities:

1. Better blood sugar control: High blood sugar can damage blood vessels in your kidneys over time. Ozempic helps regulate glucose levels, potentially slowing down or even preventing this damage.
2. Reduced inflammation: Inflammation is a known culprit in many chronic diseases, including kidney disease. Ozempic appears to have anti-inflammatory effects, which could help protect your kidneys from further harm.
3. Lower blood pressure: High blood pressure puts a strain on your kidneys. One study suggests that semaglutide, the active ingredient of Ozempic, can help lower blood pressure, easing the workload on these vital organs.

These potential benefits combined offer a compelling reason why Ozempic might be a helpful option in protecting your kidneys, especially if you’re also living with diabetes.

How to monitor your kidney health while taking Ozempic

While Ozempic is generally safe and has shown promise in supporting kidney health, everyone reacts differently to medication. That’s why your doctor needs to keep a close eye on how your kidneys are doing while taking Ozempic. 

Here’s what you and your doctor can do:

• Plan regular check-ups: Your doctor will schedule regular blood and urine tests to keep tabs on how your kidneys are doing. These tests will check things like how well your kidneys are filtering waste (your GFR) and whether there’s any protein leaking into your urine.
• Stay hydrated: Ozempic can sometimes cause nausea or vomiting, which can lead to dehydration. Dehydration is tough on your kidneys, so be sure to drink plenty of water and let your doctor know if you’re feeling dehydrated.
• Monitor electrolytes: Electrolyte abnormalities can also happen if you become dehydrated from nausea and vomiting.
• Personalize dosing: Your doctor will start you on a lower dose of Ozempic and gradually increase it, always making sure to monitor how your kidneys are responding.
• Discontinue, if needed: In rare cases, if your kidney function declines significantly while on Ozempic, your doctor will have you stop the medication. They’ll weigh the potential benefits against the risks to determine what’s best for you.

Remember, open communication with your doctor is key. Don’t hesitate to ask questions or share any concerns you have about your kidney health while taking Ozempic.

Common questions about Ozempic and kidney health

We know you might have more questions about Ozempic and its impact on your kidneys. Let’s address a few common ones:

Are there any kidney-related side effects of Ozempic?

While rare, some people might experience changes in urination frequency or acute kidney injury (AKI) when taking Ozempic. If you notice any unusual symptoms related to your kidneys, such as changes in urine output, blood in your urine, swelling in your legs or ankles, fatigue, or confusion, it’s important to consult your doctor right away.

Do I need to adjust my dose if I have kidney disease?

Your doctor will determine the appropriate dose for you based on your kidney function and overall health. You’ll start on a lower dose of Ozempic and gradually increase it as needed.

Can I take Ozempic if I’m on dialysis?

This depends on your specific situation. While Ozempic is not explicitly designated as harmful for people on dialysis, its use requires careful evaluation by your doctor. They will consider your overall health, the severity of your kidney disease, and other factors before determining if Ozempic is right for you.

Can Ozempic help prevent kidney disease if I don’t have it yet?

Current research mainly focuses on the effects of Ozempic on existing kidney disease. It may also have a role in preventing kidney damage in people with diabetes who don’t yet have chronic kidney disease. However, more research is needed.

Noom for personalized weight loss management

At Noom, we’re all about personalized solutions that fit your unique health needs.

Noom Med is here to help. If you qualify, we will connect you with a clinician who will discuss whether Ozempic or another medication is right for your specific situation. They’ll carefully review your kidney health and overall medical history, ensuring we make informed decisions together.

If you’re taking GLP-1 medications like Ozempic to manage your weight or diabetes, our GLP-1 Companion is here to guide and support you every step of the way. We understand that these medications can be an important part of your health, and our program is designed to help you maximize their benefits while minimizing any potential side effects.

Here’s what you’ll get:

• Personalized guidance: Expert advice on nutrition and fitness routines tailored just for you.
• Protein Power and Muscle Defense™: Special tools to keep track of your protein intake and exercises to help maintain those muscles while on GLP-1s.
• A workout library: A huge variety of fitness classes like yoga, HIIT, strength training, and Pilates—all at your fingertips.

At Noom, we’re your partner on this health journey. We believe in making sustainable lifestyle changes that stick, tackling both the physical and mental sides of weight management. Whether you’re exploring Ozempic or other options, we’ve got the support and guidance you need to reach your goals and feel your best.

Note: Ozempic is not FDA-approved to treat obesity or for weight loss.